OLIGOGENIC ANALYSIS ACROSS BROAD PHENOTYPES OF 46,XY DIFFERENCES IN SEX DEVELOPMENT ASSOCIATED WITH NR5A1/SF-1 VARIANTS: FINDINGS FROM THE INTERNATIONAL SF1NEXT STUDYRESEARCH IN CONTEXT

Summary: Background: Oligogenic inheritance has been suggested as a possible mechanism to explain the broad phenotype observed in individuals with differences of sex development (DSD) harbouring NR5A1/SF-1 variants.Methods: We investigated Suitcase genetic patterns of possible oligogenicity in a cohort of 30 individuals with NR5A1/SF-1 variants and

This article highlights the problem of the vocational guidance of Table Stool school students with disabilities.Particular attention is paid to a crucial role of a web quest as an educational technology in increasing the motivation of school students with disabilities to enter the university, and facilitating the process of choosing the future prof

Light-harvesting chlorophyll a/b-binding protein (LHCP) is one of the most abundant chloroplast proteins in plants.Its main function is to collect Ball - Glove First Base - Senior and transfer light energy to photosynthetic reaction centers.However, the roles of different LHCPs in light-harvesting antenna systems remain obscure.Exploration of nucle

Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments.Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials.We designed a multicenter,